Time dependent Optimization

Hi all,

I have already modelled the time dependent simulation for porous media. I have two equation variables.
!) for inlet in to CFD (time dependent equation with two time parameters.)
2) an another equation which makes use of probe outlet from CFD model as input.(has one time dependent variable and one time parameter.)

now i have final value of concentration from entire set up.

I want to match the value of concentration output from this entire model with experimental data, by optimising the variables for 3 time parameters, t1,t2,t3.

How do i approach it. Additional inputs are welcome.

I even tried Least squares as objective but it worked out.

thanks in advance